The imidazo[2,1-b]thiazole scaffold is widely present in natural and synthetic compounds with important properties or biological activities such as anti-inflammatory, antibacterial, antituberculosis, cytotoxic, anthelmintic, antihypertensive or herbicidal. The isocyanide multicomponent reaction (I-MCR) process is a greener alternative efficient synthetic tool. Herein we described a novel methodology to the one pot synthesis of imidazo[2,1-b]thiazole by Groebke-Blackburn-Bienaymé reaction using a few explored 3-formylchromone.