Catalytic aminomethylation of aliphatic and aromatic amines using (thio)urea

Regina Khayrullina

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Catalytic aminomethylation of aliphatic and aromatic amines using (thio)urea

Regina Khayrullina

¹ Institute of Petrochemistry and Catalysis of Russian Academy of Sciences

Academic Editor: Julio A. Seijas

Published: 15 November 2023 by MDPI in The 27th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-27-16251 (registering DOI)

Abstract:

To continue our research on catalytic aminomethylation, we studied the effect of catalysts on this reaction involving aliphatic and aromatic amines. We have developed an effective method for the production of cyclic and acyclic carbamide-containing compounds. It is based on the reaction between amines and 1,3-bis[dimethylamino(hydroxy)methyl](thio)urea, prepared in situ from urea or thiourea and bis(dimethylamino)methane or formaldehyde in the presence of NiCl₂•6H₂O, or CuCl₂ •2H₂O, and SmCl₃•6H₂O as catalysts.

Keywords: aminomethylation; cyclic and acyclic N-containing compounds; amines; catalyst

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Regina Khayrullina