Numerous organic and inorganic compounds, as well as transition metals, have been mentioned, as homogeneous catalyst, in chemical processes. However, the utilization of these homogeneous catalysts is inhibited by challenges such as separation of products from the reaction mixtures and the recycling of catalysts, despite their high catalytic activity resulting from the increased contact surface of the homogeneous catalysts with reactants. In recent years, various research have been accomplished on graphene oxide due to its remarkable chemical and mechanical properties. Among these applications, the use of modified graphene oxides as catalysts is of extreme importance. In this work, 1-amino-2-naphthol-4-sulfonic acid functionalized graphene oxide (GO-ANSA) was employed, as a new and highly effective heterogeneous nanocatalyst, for the preparation of tetraketone derivatives through multicomponent reaction of 1,3-diketones with aromatic aldehydes. This catalyst proceeds rapid conversion of substrates and affords high yields of the products. Furthermore, it is recyclable, easily separable and environmentally friendly.