In recent years, various research have been accomplished on the catalytic applications of chitosan and its derivatives. In this research, methyl methacrylate grafted to chitosan (Cs-MMA) was employed as a new biopolymeric nanocatalyst for the synthesis of imidazole derivatives through multi-component reaction (MCR) strategy. Characterization of the obtained nanomaterial has been done via different spectroscopic, microscopic, and analytical methods such as Fourier transform infrared (FTIR), X-ray diffraction analysis (XRD), field emission scanning electron microscopy (FESEM). This nanocatalyst showed high yields of the products and short reaction times. This heterogeneous catalyst illustrated magnificent reusability and can be used at least six times without significant loss of its activity.