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Liquid crystal gel based on sensitive pH and temperature composites
*
1
,
Ma. Belen Rauschemberger Rauschemberger
2
,
Paula V. Messina
1
Academic Editor: Humbert G. Díaz
Published:
21 December 2023
by MDPI
in MOL2NET'23, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 9th ed.
congress CHEMBIO.MOL-09: Org. Chem., Med. Chem., Mol. Biol., & Pharm. Industry Congress, Paris, France-Fargo, USA, 2023.
Abstract:
In this work, a liquid crystal system as a potential bone-repairing booster has been induced from a polyacrylic acid (PAAc) gel loaded with synthetic hydroxyapatite nanoparticles (nHA) under physiological conditions of pH and temperature that resemble the early stages of bone formation. Dynamic processes at the microscale in biological systems require a material capable of behaving following a specific order and fluency. Besides, they must fulfill conditions such as biocompatibility. The occurrence of mesophases at different environments of pH and temperature has been shown by an optical microscope with crossed polaroids and retardation plate. The biocompatibility has been demonstrated by hemolysis analysis and coagulation assays. The results have shown a biocompatible system with excellent adaptation properties under physiological in vitro conditions.
Keywords: Liquid crystals, pH, temperature, hidroxyapatite, polyacrylic acid
Comments on this paper
Maider Baltasar Marchueta
4 January 2024
Dear authors thank you for your support to the conference.
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS Brainstorming Workshop is now open until January 25th. MOL2NET committee, authors, and social media followers worldwide are invited to post questions/answers and comments about papers. Please kindly post your public Answers (A) to the following questions in order to promote interchange of scientific ideas.
My Questions (Q) to you:
Q1. Can you provide insights into the practical implications of the demonstrated biocompatibility of the liquid crystal system, particularly in terms of its adaptation properties under physiological in vitro conditions,
Q2. and how these findings contribute to the potential application of this system in bone repair?
Dear author thanks in advance for your kind support answering the questions.
Now, the conference publication phase is close but you can answer here directly as a post-publication comment.
Last but not least, please become a verified REVIEWWWER of our conference by making questions to other papers in different Mol2Net congresses. Commenting steps: login, go to papers list, select paper, write comment, click post comment.
Happy new year 2024.
Thanks and kind regards,
CHEMBIOMOL Committee Assistant, Maider Baltasar Marchueta.
Now we closed the publication phase and launched the post-publication phase of the conference. REVIEWWWERS Brainstorming Workshop is now open until January 25th. MOL2NET committee, authors, and social media followers worldwide are invited to post questions/answers and comments about papers. Please kindly post your public Answers (A) to the following questions in order to promote interchange of scientific ideas.
My Questions (Q) to you:
Q1. Can you provide insights into the practical implications of the demonstrated biocompatibility of the liquid crystal system, particularly in terms of its adaptation properties under physiological in vitro conditions,
Q2. and how these findings contribute to the potential application of this system in bone repair?
Dear author thanks in advance for your kind support answering the questions.
Now, the conference publication phase is close but you can answer here directly as a post-publication comment.
Last but not least, please become a verified REVIEWWWER of our conference by making questions to other papers in different Mol2Net congresses. Commenting steps: login, go to papers list, select paper, write comment, click post comment.
Happy new year 2024.
Thanks and kind regards,
CHEMBIOMOL Committee Assistant, Maider Baltasar Marchueta.
Luciano Benedini
4 January 2024
Dear Maider Baltasar Marchueta,
Thank you for your comments. First, this system is formed by two biocompatible components, hydroxyapatite and polyacrylic acid. We have demonstrated the biocompatibility of hydroxyapatite, and its osteoconduction and osteoinduction in other works. We also demonstrate that combined with alginate, another biopolymer is bioactive and biocompatible. In this case, we focused on the relationship between blood and coagulation vias and we demonstrated the safety of this system. We have to do the next step by applying this system in culture cell lines. We propose this system as filler material for small bone defects due to its capability to form tridimensional arrangements with calcified deposits.
Thank you for your comments. First, this system is formed by two biocompatible components, hydroxyapatite and polyacrylic acid. We have demonstrated the biocompatibility of hydroxyapatite, and its osteoconduction and osteoinduction in other works. We also demonstrate that combined with alginate, another biopolymer is bioactive and biocompatible. In this case, we focused on the relationship between blood and coagulation vias and we demonstrated the safety of this system. We have to do the next step by applying this system in culture cell lines. We propose this system as filler material for small bone defects due to its capability to form tridimensional arrangements with calcified deposits.
Humbert G. Díaz
13 January 2024
Dear author(s), Thank you for your contribution to our conference!!!
We have a question for you, you can read and answer bellow.
Question for Authors:
What could be the Strengths, Weaknesses, Opportunities, and Threats (SWOTs) of incorporating Hyaluronic acid to your formulation?
What are better candidate species for such studies according to your experience?
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Sincerely yours
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We have a question for you, you can read and answer bellow.
Question for Authors:
What could be the Strengths, Weaknesses, Opportunities, and Threats (SWOTs) of incorporating Hyaluronic acid to your formulation?
What are better candidate species for such studies according to your experience?
REVIEWWWERS'23 participation:
We also invite you to participate in the REVIEWWWERS Workshop, which is now open,
making questions to other authors. The steps are very easy. instructions:
Step(1), Sign in/Login here to Sciforum platform https://login.mdpi.com/login.
Step(2), Go to presetations list [MOL2NET'23 Papers List] https://mol2net-09.sciforum.net/presentations/view.
Step(3), Scroll down papers list and click on one title of the communication you selected.
Step(4), Scroll down and click on Commenting button, post your comment, and click submit.
Step(5), Repeat review process for other papers including across comments in othe conference congresses.
Step (6), Check your email for responses from the authors and counter-argue/thank them for it.
Step (7), Remember to check your email if you have had questions about your own work(s) and answer them.
Step(8), Request your attendance certificate at Email: mol2net.chair@gmail.com.
Sincerely yours
MOL2NET Team
