Synthetic and Kinetic Study of the Reaction of 3-Formylchromones with Aromatic Amino Acids

Henrieta Stankovicova; Margita Lacova; Anton Gaplovsky; Jarmila Chovancova; Nada Proyanova

doi:10.3390/ecsoc-2-01682

Previous Article in event

Reaction of 4,5-Dihydroxyimidazolidine-2-ones with Arylsulfinic Acids

Next Article in event

A Simple Synthesis of the Aryloxy- or Arylthio- derivatives of 2-Benzothiazolyl Stilbenes

Synthetic and Kinetic Study of the Reaction of 3-Formylchromones with Aromatic Amino Acids

Henrieta Stankovicova

^{*

1},

Margita Lacova

^{*

2},

Anton Gaplovsky

¹,

Jarmila Chovancova

²,

Nada Proyanova

¹ Institute of Chemistry and Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, SK-842 15 Bratislava, Slovakia
² Department of Organic Chemistry and Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-2, SK-842 15 Bratislava, Slovakia
³ Central Laboratories, Faculty of Chemical Technology, Slovak University of Technology, Radlinského 9, SK-812 37 Bratislava, Slovakia

Published: 01 November 1998 by MDPI in The 2nd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-2-01682

Abstract: Conditions of synthesis of 2-alkoxy- or 2-hydroxy-3-(arylaminomethylene)-4-chromanones and 3-(aryliminomethyl)-4-chromenones in the reaction of 3-formylchromones with arylaminoacids have been investigated. The alkylation of 2-alkoxy-3-(arylaminomethylene)-4- chromanones by alkylhalides was carried out. Rate coefficients for the acid-catalyzed formation of chromanone-chromenone system were measured. Dependence of reaction rate upon the structure of starting compounds, the type of used reaction medium and the concentration of catalyst, respectively, have been studied.

Keywords: 4-oxochromene-3-carboxaldehydes; anils; enamines; reaction kinetics, rate constants Introduction

View paper

44 Reads
0 Recommendations

Henrieta Stankovicova

Margita Lacova

Anton Gaplovsky

Jarmila Chovancova

Nada Proyanova