Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers

Györgyi Kovács; Zoltán Timár; Zoltán Kele; Lajos Kovács

doi:10.3390/ecsoc-4-01883

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Optimization of peptide nucleic acid (PNA) oligomer synthesis using Fmoc/acyl-protected monomers

Györgyi Kovács

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Zoltán Timár

Zoltán Kele

Lajos Kovács

¹ Nucleic Acids Laboratory, Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary

Published: 11 September 2000 by MDPI in The 4th International Electronic Conference on Synthetic Organic Chemistry session Solid Phase Chemistry and Combinatorial Synthesis

https://doi.org/10.3390/ecsoc-4-01883

Abstract: The optimization of peptide nucleic acid (PNA) oligomer synthesis was carried out using Fmoc/acyl-protected monomers on NovaSyn® hydroxy-Tentagel resin and HATU/DIPEA/lutidine activation. The sequences H-Leu-ttttt- Gly-NH2 (1) and H-Gly-cgg-act-aag-tcc-att-gc-Gly-NH2 (2) were prepared and characterized by electrospray mass spectrometry

Keywords: n/a

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Györgyi Kovács

Zoltán Timár

Zoltán Kele

Lajos Kovács