Ensuring food security and safety by guaranteeing the quality of inputs that enter the crop production continuum is an important aspect of research and development. It is based on this premise that this research investigation was conducted, cutting across the foregoing areas of concern. This study aimed to determine the effect of compost-based soil amendments applied in various forms on the production performance, the lead (Pb) and cadmium (Cd) dynamics in soil, and the uptake of selected crops. Field experiments were established using four selected food crops: radish (Raphanus sativus), cucumber (Cucumis sativus), sweetcorn (Zea mays var. saccharata), and kangkong (Ipomoea reptans) treated with different forms of compost-based soil amendment, namely vermicast, vermi tea, and ordinary compost following a Randomized Complete Block Design with three replications. Standard cultural management practices for the culture of each crop were followed. Growth and yield data were gathered for each crop and analyzed statistically. The initial concentrations of Pb and cadmium Cd in thesoil in the experimental area were recorded. The soil was also sampled at the end of every cropping season to determine the changes in the Pb and Cd level. The different economically important parts of the crop were subjected to plant tissue analysis to determine the heavy metal (Pb and Cd) uptake. The results revealed that better growth and yield of radish, cucumber, sweetcorn, and kangkong were attained with the application of vermicast. Application of solid forms of compost-based soil amendment, namely vermicast and ordinary compost, favored net accumulation of Pb in soil grown with radish and cucumber, while vermi tea application favored net uptake. There was net accumulation of Pb in soil in which sweetcorn was grown, regardless of the form of compost that was applied. Kangkong proved to be a hyperaccumulator plant in terms of Pb uptake regardless of the compost used.