The cosmetics industry is undergoing a significant transformation, driven by the escalating demand for naturally derived ingredients and advanced delivery systems. This abstract explores the exciting convergence of plant-based bioactives and cutting-edge nanotechnology in developing next-generation cosmeceuticals. We delve into how nanocosmetics, leveraging diverse nanocarriers like niosomes, nanofibers, and nanoemulgels, revolutionize the efficacy and targeted delivery of active compounds. This approach moves beyond mere aesthetics, aiming to offer genuine therapeutic benefits for skin health by enhancing ingredient stability, solubility, and controlled release. These nano-formulations precisely encapsulate and direct beneficial molecules to specific skin layers, optimizing therapeutic impact while minimizing potential side effects.

Our research directly contributes to this paradigm shift. We employ a rigorous, multi-faceted approach, integrating in vitro enzyme inhibition assays, sophisticated in silico molecular docking and toxicity assessments, and comprehensive cell-based studies to pinpoint high-potential plant extracts and natural compounds. This meticulous screening has led to several successful laboratory-scale formulations. For instance, we have successfully incorporated Cotinus coggygria extracts into innovative niosome, nanofiber, and nanoemulgel systems, demonstrating enhanced skin delivery and biological activity. Furthermore, our team has developed a patent-pending anti-acne formulation based on a unique blend of plant extracts specifically targeting Propionibacterium acnes. We also highlight the broader potential of these nanoforms beyond cosmetics, as shown by our recent development of polycaprolactone (PCL) electrospun nanofibers loaded with Cotinus coggygria extract and hyaluronic acid (HA) for advanced wound healing applications. This talk will showcase our latest breakthroughs in crafting these innovative, phyto-based nanocosmeceuticals.