This study aims to provide the first comprehensive checklist and analysis of the Chiococceae tribe in Mexico, based on more than 4,000 herbarium specimens and georeferenced occurrence records cross-validated from online repositories. A total of 28 species across nine genera were recorded, including two endemic genera ( Coutaportla and Nernstia ) and 14 species restricted to the country. Approximately half of the Chiococceae species occurring in Mexico are endemic, underscoring the country as a centre of diversity for the tribe. Distribution patterns show a strong concentration in the tropical south, particularly in Chiapas (17 species; five endemic), Veracruz (14 species; four endemic), and Oaxaca (14 species; six endemic). Diagnostic combinations of reproductive traits—such as corolla form, size, and symmetry; fruit texture and dehiscence; and seed morphology—proved valuable for distinguishing genera. However, persistent taxonomic challenges remain at both generic (e.g., Asemnantha/Chiococca, Coutaportla/Lorencea, Solenandra/Exostema) and species levels (e.g., Chiococca alba), highlighting the need for further systematic research. Overall, this work establishes a baseline for future taxonomic, ecological, and conservation studies on Chiococceae in Mexico.