This paper presents a comprehensive review of the current state of knowledge regarding the crystalline architecture and solid-state behavior of Mansorin A, a key bioactive secondary metabolite isolated from the heartwood of Mansonia gagei. Despite its recognized pharmacological potential, including its antifungal and cytotoxic effects, the physical chemistry of its crystalline form is often overlooked. This paper systematically categorizes the existing crystallographic data to provide a holistic understanding of how molecular structure dictates the material properties of this natural product. The analysis focuses on the supramolecular assembly of Mansorin A, highlighting the role of the planar naphtofurane-type skeleton in promoting specific molecular arrangements. The reported unit cell parameters and the hierarchy of non-covalent interactions are examined, specifically emphasizing the π- π stacking motifs and the complex networks of C-H···O hydrogen bonds that stabilize the lattice. Furthermore, this review evaluates the impact of polymorphism and solvate formation on the solubility and thermodynamic stability of the compound. By synthesizing data from chemical, structural, and pharmacological studies, this review identifies critical gaps in the current research, particularly concerning the structure–property relationships that affect the bioavailability of Mansorin A. It is concluded that a deeper understanding of its crystal engineering aspects is essential for developing effective delivery systems. This work serves as a foundational resource for researchers aiming to optimize the formulation of Mansorin-based compounds for future therapeutic applications.