Higher education institutions increasingly face pressure to demonstrate social relevance while navigating growing oversight, epistemic policing, and constraints on academic freedom. There remains limited empirical research on how Collaborative Online International Learning (COIL), when integrated with social entrepreneurship frameworks, facilitates critical engagement with socially sensitive issues such as addiction, stigma, and reintegration. Grounded in transformative learning theory and global citizenship education, this qualitative study examines student reflections from a COIL module involving students from Malaysian and United States universities. The module integrated social entrepreneurship tools; Mission Model Canvas into coursework focused on real-world social problems such as substance use disorder and HIV-related stigma. Data were drawn from 30 student discussion board reflections collected over a five week COIL module. Reflections were guided by structured prompts focusing on problem analysis, intercultural learning, and solution design. Using thematic analysis, following a systematic coding process involving multiple coders, three key themes emerged. First, structured problem analysis, where students reported that frameworks such as the Mission Model Canvas enabled them to transform abstract social issues into structured intervention strategies. Second, global perspective and contextual awareness, as exposure to cross-cultural discussions highlighted how substance abuse and crime-related harms are shaped by cultural and institutional contexts. Third, pedagogical challenges in digital collaboration, including time-zone barriers and unfamiliarity with digital platforms, limited deeper international engagement but still facilitated indirect intercultural learning. The findings suggest that structured innovation tools can act as mediating pedagogical mechanisms that translate critical reflection into applied problem-solving, supporting deeper transformative learning processes. This study contributes theoretically by bridging COIL pedagogy with social entrepreneurship and transformative learning frameworks, offering a more integrated model of intercultural, practice-oriented education. Practically, it highlights key design considerations for implementing COIL modules across institutional contexts, including the need for culturally responsive, and strategies to mitigate digital collaboration constraints.