The article presents only the author’s view on the formation of the notion of information. The basic idea is that the information comes into existence with the emergence of organic molecular structures of increasing complexity. In the prebiotic physico-chemical systems, emerging molecules are carriers of structural inert information that reflects the fixed coordinates of the atoms in the molecule being in a stable state. Emerging irregular polymers (RNA world) acquire the potential of the digital encoding and transmission of information messages. Their structural information contained in the sequence of nucleotides evolved into symbolic (prescriptive) information in the process of molecular semiosis. It would be more accurate to say that these molecules as a result of natural evolution and selection for survival become operational. The meaning of this term is that the memory fixed in a sequence of monomers forming these molecules can now be used not only for the reproduction of its own structure, but also in a symbolic form can be employed in the biosynthesis of another class of polymers (proteins).