Objective: This systematic review aims to synthesize the current evidence from preclinical and clinical studies on the application of Theravex Technology (TTech) (formerly known as bone bioactive liquid “BBL”) in improving postoperative outcomes in dentistry.
Methods: A comprehensive literature search was conducted across PubMed, Scopus, ScienceDirect, Cochrane Library, and Google Scholar for studies published up to March 2026. Eligible studies were selected according to predefined PICOS criteria. The outcomes were analyzed using the random-effects model on Rstudio with results reported as risk ratios (RRs) and 95% confidence intervals (CIs), and a p-value of less than 0.05 was set as a significant result. Trial Sequential Analysis (TSA) was conducted using TSA software to evaluate the required information size (RIS) and control for random errors.
Results: Four studies encompassing 526 treated sites were included in this review. Meta-analysis results of postoperative healing demonstrated a significant benefit of TTech, with a RR of 7.19 (95% CI: 2.24; 23.13; p = 0.0009). These findings were further validated by TSA, which confirmed robustness by crossing the TSA boundaries, but the cumulative number of subjects did not reach the RIS. Narrative synthesis results from a preclinical study consistently showed that BBL-treated implant surfaces achieved significantly greater bone-to-implant contact, increased inter-thread bone area, and reduced crestal bone loss compared with conventional surfaces. Clinically, TTech was associated with improved implant stability, enhanced osseointegration on CBCT, and accelerated soft tissue healing. Compared to chlorhexidine mouthwash, TTech promoted earlier pain relief and superior early wound healing, highlighting its potential to optimize both hard and soft tissue recovery following implant therapy.

Conclusion: Current evidence positions TTech as a promising bioactive agent in dentistry, with beneficial effects on osseointegration, soft tissue healing, and postoperative pain reduction. Further long-term clinical studies are crucial to confirm its sustained effectiveness and establish standardized treatment protocols.