Some novel 1,4,5,2-oxadiazaphosphinines, 1,3,2-benzoxazaphosphinines and α-hydrazino-phosphonic acid bearing a chromone ring have been obtained from reaction of 2-hydroxy-N`-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide (2) with some phosphorus reagents such as phosphonic acid and its diesters, phosphorus sulfides and phosphorus halides in dry dioxane. The compounds were evaluated for their anticancer activities and on the expression of VEGF inhibition. Among the synthesized compounds, compounds 3 and 7 exhibited high effect against breast cancer cells MCF-7 in comparison with the standard drug and on the expression of VEGF inhibition.
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Reaction of 2-hydroxy-N`-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide with some phosphorus reagents: Synthesis and evaluation of anticancer activities of some novel α-hydrazinophosphonic acid, 1,4,5,2-oxadiazaphosphinines and 1,3,2-benzoxaza-phosphinines bearing a chromone ring.
Published: 01 November 2016 by MDPI in The 20th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry
Keywords: Chromone, Hydrazone, 1,4,5,2-Oxadiazaphosphinines and 1,3,2-Benzoxazaphosphinines, Anticancer, VEGF