A series of imine analogs of anticancer drug imatinib were synthesized in moderate to good yields, under ecofriendly conditions. Some compounds containing fluorine atoms and important medicinal chemistry scaffolds such as chromone, pyridine and pyrrole. These compounds could have potential applications in medicinal chemistry as antifungal, antibacterials and mainly Abl tyrosine kinase inhibitors.
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Synthesis of novel complex conjugated imines containing a fragment of the anticancer drug imatinib
Published: 03 November 2017 by MDPI in The 21st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: conjugated Imines, ecofriendly, Imatinib, Phenylaminopyrimide (PAP)