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Synthesis of novel Schiff base Derivates containing a fragment of the HIV Integrase Inhibitor drug Raltegravir
CARLOS JESUS CORTES-GARCIA * 1 , Jairo Jesús Rojas-Ortiz 1 , Claudia Contreras-Celedón 2 , Mario Gómez-Hurtado 3 , Luis Chacón- García 2
1  laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
2  Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México
3  laboratorio de Productos Naturales, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Ciudad Universitaria, C.P. 58033, Morelia, Michoacán, México

10.3390/ecsoc-23-06462
Abstract:

An eco-friendly methodology for the synthesis of novel Schiff base analogs of Raltegravir, an integrase inhibitor drug, is described. Thus, pertinence of these imine derivatives is related to Medicinal Chemistry to develop new anti-HIV compounds. Based on thorough search of the relevant literature, this is the first report of the synthesis of Schiff base using a Raltegravir drug fragment as amino component. In addition, these imines will be used as a synthetic precursor to prepare other biologically relevant nitrogen heterocycles, such as 1,5-disubstituted tetrazoles.

Keywords: Raltegravir, Schiffs base, Complex imines, combinatorial chemistry
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