2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione prepared by reaction of Meldrum’s acid with triethyl orthoformate and aniline, reacts with active methylene nitriles to afford 2-oxo-1,2-dihydropyridine-3-carboxylic acid derivatives useful as drug precursors or perspective ligands.
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SYNTHESIS OF NEW 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES
Published: 14 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis
Keywords: nicotinic acids, Meldrum’s acid, 2-oxo-1,2-dihydropyridine-3-carboxylic acid, cyanothioacetamide, cyanoacetamide.