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Asymmetric Biginelli-like reaction catalyzed by chiral TADDOL-derived phosphoric acid bearing two hydroxyl groups
Published:
15 November 2019
by MDPI
in The 23rd International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
Several new chiral TADDOL-derived phosphoric acids bearing two hydroxyl groups have been successfully synthesized via highly regioselective 2,3-cyclosulfitation as asymmetric catalysts for Biginelli-like reaction. The obtained results clearly demonstrated that these catalysts are able to effectively catalyze the reactions with good to excellent enantioselectivities. A control experiment indicated that two hydroxyl groups are indispensable for high enantioselectivity of the Biginelli-like reaction.
Keywords: asymmetric Biginelli-like reaction; chiral phosphoric acids ; regioselective 2,3-cyclosulfitation
