Synthesis of Imidazo[1,2-a]pyridine-chromones via ultrasound-assisted Groebke-Blackburn-Bienaymé Reaction

Carlos Zarate Hernández; Manuel Alejandro Rentería Gómez; María Rocío Gámez Montaño

doi:10.3390/ecsoc-23-06652

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Synthesis of Imidazo[1,2-a]pyridine-chromones via ultrasound-assisted Groebke-Blackburn-Bienaymé Reaction

Carlos Zarate Hernández

Manuel Alejandro Rentería Gómez

María Rocío Gámez Montaño

¹ Universidad de Guanajuato, División de Ciencias Naturales y Exactas, Departamento de Química

Published: 15 November 2019 by MDPI in The 23rd International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-23-06652

Abstract:

A serie of imidazo[1,2-a]pyridine-chromones were synthesized by ultrasound-assisted Groebke–Blackburn–Bienaymé reaction (GBBR) under eco-friendly conditions (20 mol% ammonium chloride catalyst in EtOH). Chromones and imidazo[1,2-a]pyridines are a privileged class framework of high interest in medicinal chemistry because they are present in numerous compounds showing relevant biological activities.

Keywords: multicomponent reactions; imidazo[1,2-a]pyridine; GBBR; chromone; green chemistry

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Carlos Zarate Hernández

Manuel Alejandro Rentería Gómez

María Rocío Gámez Montaño