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Synthesis of Imidazo[1,2-a]pyridine-chromones via ultrasound-assisted Groebke-Blackburn-Bienaymé Reaction
Published:
15 November 2019
by MDPI
in The 23rd International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract:
A serie of imidazo[1,2-a]pyridine-chromones were synthesized by ultrasound-assisted Groebke–Blackburn–Bienaymé reaction (GBBR) under eco-friendly conditions (20 mol% ammonium chloride catalyst in EtOH). Chromones and imidazo[1,2-a]pyridines are a privileged class framework of high interest in medicinal chemistry because they are present in numerous compounds showing relevant biological activities.
Keywords: multicomponent reactions; imidazo[1,2-a]pyridine; GBBR; chromone; green chemistry
