Nitrogen and sulfur-containing fused heterocyclic molecules can be highly valuable for obtaining biological leads and exploring drug discovery programs. Thiazolo-fused heterocyclic fragments are interesting in pharmaceutical and biomedical research since these scaffolds occur in several natural and biologically active molecules such as anticonvulsant, antidiabetics, antihelminthics and also has depressant effect on the central nervous system.

In our studies, we synthesized and optimized some novel class of thiazolo[3,2-a]pyrimidine derivatives by multicomponent reaction of 2-aminothiazole with aldehydes aromatic and methylene acids, trying to meet some criteria of green chemistry.