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Design and synthesis of novel alfa-mangostin-nitroimidazole hybrids with toxic effects on amastigotes of Trypanosoma cruzi
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Paulo Pitasse Santos
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Gabriella Calheiros Magalhães
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Published:
06 November 2020
by MDPI
in 6th International Electronic Conference on Medicinal Chemistry
session Round Table on Parasitic Diseases
Abstract:
alfa-Mangostin (MGT) is the main product isolated from the the fruit pericarp of Garcinia mangostana. This xanthone exhibits important toxic effects on T. cruzi forms amastigotes. We describe herein the synthesis of new hybrid derivatives of MGT and nitroimidazoles using click reaction as the key-step. Toxic effects on intracellular amastigotes of T. cruzi (Tulahuen C2C4 LacZ).
Keywords: antiparasitic chemotherapy, Chagas disease, click reaction, Garcinia mangostana, molecular hybridization
