Synthesis of 1,2,3-triazoles from alkyne-azide cycloaddition catalyzed by a bio-reduced alkynylcopper (I) complex

Josué Varela-Palma; Jaime González; Gustavo Lopez-Téllez; M. V. Basavanag Unnamatla; Marco A. García-Eleno; Erick Cuevas-Yañez

doi:10.3390/ecsoc-24-08384

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Synthesis of 1,2,3-triazoles from alkyne-azide cycloaddition catalyzed by a bio-reduced alkynylcopper (I) complex

Josué Varela-Palma

Jaime González

Gustavo Lopez-Téllez

M. V. Basavanag Unnamatla

Marco A. García-Eleno

Erick Cuevas-Yañez

¹ Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 50200, Mexico
² Facultad de Química, Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico

Published: 14 November 2020 by MDPI in The 24th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-24-08384

Abstract:

A small library of 1,2,3-triazoles was synthesized from diverse alkynes and azides using catalytic amounts of an alkynylcopper (I) complex which in turn was prepared from direct treatment of phenylacetylene with Fehling reagent in presence of glucose as reducing agent. The results suggest that CuAAC reaction requires only 0.5 mg/mmol copper (I) phenylacetylide without any further additives.

Keywords: 1,2,3-triazole, alkynylcopper(I) complex, click chemistry, bio-reduced catalyst

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