This study investigates the curative response of ethanol extract of Cassia sieberiana leaves (EECSL) on testosterone-induced benign prostatic hyperplasia (BPH). Thirty rats (120-160 g) were grouped into six of five rats each. Group 1 was the normal control; groups 2-6 were induced with testosterone (5 mg/kg body weight) for twenty-one days following standard procedures. Group 2 serves as BPH-control, groups 3 received finasteride while 4-6 received orally 100, 300, and 500 mg/kg of EECSL respectively for 14 days. Biochemical and BPH indices were analyzed. Oral administration of EECSL showed a decrease in prostate weight, Prostate specific antigen (PSA), testosterone and dihydrotestosterone (DHT), triacylglycerol (TAG), total cholesterol (TC), low density lipoprotein (LDL), malondialdehyde (MDA), aspartate aminotransferase (AST) alanine aminotransferase (ALT) whereas an elevation in High density lipoprotein (HDL), GSH and likewise antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) activities were recorded. The histology photomicrograph showed that EECSL restored lesions of testosterone induction in the treated groups. Our study reveals that EECSL exerts potent on BPH, hypolipidaemic, and antioxidant potentials and justifies the claims by the traditional doctors in BPH management.