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Polynuclear silver(I) complex with thianthrene: structural characterization, antimicrobial activity and interaction with biomolecules
* 1 , 2 , 3 , 2 , 3 , 3 , 4 , 4 , 5 , 2
1  University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia
2  University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia
3  Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia
4  University of Ljubljana, Faculty of Chemistry and Chemical Technology, Večna pot 113, SI-1000, Ljubljana, Slovenia
5  Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia

Published: 09 November 2020 by MDPI in The 1st International Electronic Conference on Applied Sciences session Chemistry
Abstract:

Silver(I) complexes showed a wide range of applications in medicine as effective antiseptic, antibacterial and anti-inflammatory agents. Antimicrobial properties of silver(I) complexes have been well known since the successful use of cream containing silver(I) sulfadiazine for the treatment of burn wounds. The critical factor in determining the antimicrobial activity of silver(I) complexes is the type of the ligand donor atom bound to the Ag(I) ion. In this respect, in the last few decades, research has been focusing on the synthesis of silver(I) complexes with sulfur-donor ligands, including mercaptan, thioamide and thione ligands. Herein, new silver(I) complex with thianthrene (tia), [Ag(NO3)(tia)(H2O)]n, was synthesized by the reaction of AgNO3 with an equimolar amount of tia in ethanol/dichlormethane (v/v 1:1) at room temperature, and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. The antimicrobial activity of the synthesized complex was evaluated against the broad panel of Gram-positive and Gram-negative bacteria and Candida spp. This complex showed significant activity toward important human pathogens Gram-positive Staphylococcus aureus and Candida parapsilosis with minimal inhibitory concentrations (MICs) being 3.91 µg/mL. The interaction of [Ag(NO3)(tia)(H2O)]n with calf thymus DNA (ctDNA) and bovine serum albumin (BSA) was studied to evaluate the binding affinity towards these biomolecules for possible insights on the mode of antimicrobial activity. The binding affinity of the investigated complex to BSA is higher than that for DNA, indicating that proteins could be more favorable binding sites for this complex in comparison to the nucleic acids.

Keywords: Silver(I) complexes; Thianthrene; Antimicrobial activity; DNA/BSA interaction
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