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Development of a Solid Self-Emulsifying Drug Delivery System of a Weakly Basic BCS Class II Drug
1 , 1 , * 2
1  Istanbul University, Faculty of Pharmacy, Pharmaceutical Technology Department
2  Istanbul University

Abstract:

Self-emulsifying systems are becoming increasingly popular for oral delivery of poorly soluble drugs. They are divided into subgroups according to their components; Type IV formulations are prepared using only surfactants and/or co-surfactants. The aim of the study was to increase the solubility of Tadalafil, a weakly basic BCS Class II drug, by preparing Type IV formulations and using porous adsorbents. In this study, Labrasol, Kolliphor PS 20, Kolliphor PS 60, Kolliphor PS 80, Kolliphor CS 12, Kolliphor CS 20, Kolliphor HS 15, Kolliphor EL, Kolliphor ELP, Kolliphor PEG400, Gelucire 44/14 and Gelucire 48/16 were used as surfactants; Transcutol was used as a co-surfactant. The Kolliphor PS 80, Kolliphor EL, Kolliphor HS 15 formulations were prepared with a ratio of 2:1 with Transcutol to form droplet sizes less than 50 nm and PDI values below 0.2. The formulations sensitivity to heat change and pH change was analysed by performing stability tests. Stable formulations of Tadalafil were obtained using the formulations were prepared using Transcutol and Kolliphor PS 80 or Kolliphor EL. Solidification of the optimum Type IV formulations were made using Fluorite, Neusilin US2, Neusilin FL2, Syloid 3050 and Syloid 3150. Dissolution studies of the prepared Solid Type IV (S-Type IV) formulations were first performed in 0.1 N HCl, and the dissolution of the optimum S-Type IV formulations were examined in pH 4.5 and pH 6.8. It was determined that the S-Type IV formulations prepared with Neusilin US2 and Neusilin UFL2 (2:1) had provided a dissolution of over 80% at the end of the 1st minute. The results indicated the potential bioavailability improvement of S-Type IV self-emulsifying delivery system for a BCS class II drug, Tadalafil due to great enhancement in its dissolution rate.

Keywords: Self emulsifying drug delivery systems; Tadalafil; Lipid based drug delivery systems; Dissolution; Solidification; Porous cariers
Comments on this paper
Andrea Erxleben
Question
Very interesting work. Have you looked at Kolliphor PS80:Transcutol ratios other than 2:1 or what was the rationale for using a 2:1 ratio?
burcu mesut
Dear Dr. Erxleben,

First of all, thank you for your interest. We performed the test at 3 different ratios (1:1, 1:2, and 2:1), and we obtained the best result at 2:1.

Kind Regards,
Dr. Burcu Mesut



 
 
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