Biomolecules Webinar | Role of NRF2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches II
Meet Our Speakers
Dr. Isabel Lastres-Becker
Department of Biochemistry, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain, Instituto de Investigaciones Biomédicas "Alberto Sols", UAM-CSIC, Madrid, Spain, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain, Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain, Institute Teófilo Hernando for Drug Discovery, Universidad Autónoma de Madrid, Madrid, Spain;
Dr. Isabel Lastres-Becker has more than 20 years of experience in the field of neurodegenerative diseases. The study of neurodegenerative diseases has been at the focus from the beginning of her doctoral thesis and until now, the thread that has guided her entire scientific career. Her work is focused on the molecular bases of neurodegeneration related to proteinopathy, neuroinflammation, and oxidative stress. She is the head of the laboratory of “New therapeutic strategies in neurodegenerative diseases: Parkinson's disease (PD), tauopathies and amyotrophic lateral sclerosis (ALS)”. The research projects she has developed have a multidisciplinary approach that combines basic and translational research, using cell culture techniques, murine models (transgenic mice and adeno-associated viral vectors), and postmortem samples from patients with AD, PD, and ALS. She is engaged in the development of advanced biological markers, new drugs, and appropriate technology toward establishing treatments for those diseases.
Sponsors and Partners
Organizer
On Monday, 30 May 2022, MDPI and the Journal Biomolecules organized the 9th Webinar on Biomolecules, entitled "Role of NRF2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches II”. This online seminar was chaired by Dr. Isabel Lastres-Becker from the Department of Biochemistry, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain. The three speakers Prof. Dr. Antonio Cuadrado, Dr. Albena T. Dinkova-Kostova, and Prof. Dr. Giles E. Hardingham discussed the relevance of the transcription factor NRF2 in the development of different pathologies and the therapeutic implications that the modulation of this pathway can have.
The first speaker to kick off the webinar was Prof. Dr. Antonio Cuadrado from the Autonomous University of Madrid, Spain. He showed how the NRF2-KEAP1 signalling pathway can be targeted pharmacologically to treat neurodegenerative diseases. Dr. Albena T. Dinkova-Kostova, from the University of Dundee, United Kingdom, followed with her presentation on targeting KEAP1 with electrophiles and KEAP1-NRF2 protein-protein interaction inhibitors for disease prevention and treatment. Finally, Prof. Dr. Giles E. Hardingham, from the UK Dementia Research Institute and the University of Edinburgh, United Kingdom, presented the adaptive protective responses of glial cells to Alzheimer’s Disease pathology. Their presentations were followed by Q&A sessions moderated by the chair.
The webinar was offered via Zoom and required registration to attend. The full recording can be found below. In order to stay updated on the next webinars on Biomolecules, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.
Guest Editor: Prof. Isabel Lastres-Becker
Deadline for manuscript submissions: 15 August 2022