Cells Webinar | The Pathomechanism of Mitochondrial Diseases
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11th Webinar on Cells
The Pathomechanism of Mitochondrial Diseases
Mitochondria harbor many vital biochemical pathways and play crucial roles in cellular functions, including apoptosis and calcium hoeostasis. However, their primary task is to provide cellular energy via oxidative phosphorylation (OXPHOS). Mitochondrial diseases are a heterogenous group of common inborn errors of metabolism, originating from pathogenic variants in the mitochondrial or nuclear genome, resulting in OXPHOS deficiency, mostly with devastating consequences. Furthermore, mitochondrial dysfunction is also associated with numerous other pathological conditions, including neurodegenerative diseases, diabetes, cancer, immune dysfunction, and heart and kidney diseases.
This webinar features several eminent experts in mitochondrial biology, who study function and metabolic adaptation to stress and diseases in different model systems.
Date: 11 October 2021
Time: 4:00 pm CEST | 10:00 am EDT | 10:00 pm CST Asia
Webinar ID: 864 9851 7924
Webinar Secretariat: cells.webinar@mdpi.com
Meet Our Speakers
Prof. Dr. Ann Saada
Department of Genetics Hadassah Medical Center and Faculty of Medicince the Hebrew University of Jerusalem, Israel;
Dr. Ann Saada (Reisch) is interested in the pathomechanism of inborn errors of metabolism. After studying Microbiology (PhD Supervisor, Prof.Itzak Kahane) and Neurobiology (Post.Doc, Host Prof. Shlomo Rothshenker) at the Hebrew University of Jerusalem Israel, she joined the Metabolic Disease Unit, Shaare Zedek Medical Center in Jerusalem (headed by Prof Orly Elpeleg). There, she directed the Enzyme Diagnostics Laboratory. In 2005, the unit transferred to, and merged with, the Genetics Deparment at Hadassah Medical Center, where she managed the Enzyme Diagnostic Laboratory, and subsequently also the Metabolite Diagnostics Laboratory. In parallel with diagnostic services, she is an independent researcher, who joined the Faculty of Medicine, Hebrew University of Jerusalem, where she is now an Associate Professor. Her research group, which is funded by exernal research grants, (presently the Israel Science Foundation (ISF)), focuses on the pathomechanism of nuclear encoded, mitochondrial diseases, and in collaborations, the mitochondrial respiratory chain in neurodegenerative diseases and diabetes.
On Monday, 11 October 2021, MDPI and the Journal Cells organized the 11th webinar on Cells, entitled "The Pathomechanism of Mitochondrial Diseases". Chaired by Prof. Dr. Ann Saada from the Hadassah Medical Center and the Hebrew University of Jerusalem, the webinar discussed mitochondrial function and its metabolic adaptation to stress and diseases.
The first speaker to kick off the webinar was Prof. Dr. Martin van der Laan, who discussed the biogenesis and functional architecture of mitochondrial membranes. Prof. Dr. Orna Elroy-Stein followed with her talk on the defective energy status of astrocytes in eIF2B-Leukodystrophy. Finally, Dr. Sarah Weksler-Zangen discussed if type 2 diabetes can be considered a primary mitochondrial disorder. Q&A sessions were conducted after each speaker to answer any questions submitted by live online audience and a short discussion was held at the end of the webinar.
The webinar was offered via Zoom, and registration was required for attendance. The full recording can be found below. To stay updated on upcoming Cells webinars organized by MDPI, be sure to sign up for our newsletter by clicking on “Subscribe” at the top of the page.
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