13:00-13:45

Check-In

13:45-14:00

Opening Ceremony

S1. Molecules Against Cancer (Part 1)

chaired by Rino Ragno

14:00-14:30

Swen Hoelder
Invited Speaker

A tricycle journey to in vivo inhibitors and degraders of the oncogenic transcription factor BCL6

The Institute of Cancer Research, UK

14:30-14:45

Giuseppe La Regina

Induction of Ferroptosis by New Pyrrole Tubulin Assembly Inhibitors

Sapienza University of Rome, Italy

14:45-15:00

Marta Jędrzejczyk

Triphenylphosphonium salts of salinomycin as antiproliferative agents targeting the mitochondria

Adam Mickiewicz University, Poland

15:00-15:15

Diana Aleksanyan

Anticancer potential of Pd(II) pincer complexes derived from thiophosphoryl-functionalized amides

Nesmeyanov Institute of Organoelement Compounds, Russia

15:15-15:30

Victoria Mora

EU-OPENSCREEN: an open access initiative in chemical biology to support anti-cancer drug discovery

EU-OPENSCREEN ERIC, Campus Berlin Buch, Germany

15:30-15:45

Carla Marisa Magalhães

Synchrotron-Radiation FTIR-Based Investigation of the Anticancer Activity of Metabolic Products of a Marine Bioluminescent System

University of Porto, Portugal

15:45-16:15

Coffee Break

S1. Molecules Against Cancer (Part 2)

chaired by Rino Ragno

16:15-16:30

Roman Dembinski

Dicobalt Hexacarbonyl Furopyrimidine Nucleosides with Alkynyl Substituent and their Antiproliferative Activity

Oakland University, USA

16:30-16:45

Iván Rodríguez-Pampín

Reprogramming the Immune System using Multi-Target A2AAR-A2BAR Antagonists for Cancer Therapy

University of Santiago de Compostela, Spain

S2. RNA-Targeting Small Molecule Drugs and Degraders (Part 1)

chaired by Roman Dembinski

16:45-17:15

Alessandra Magistrato
Invited Speaker

Small-molecule modulators of pre-mRNA splicing

IOM at The International School of Advanced Studies, Italy

17:15-17:30

Barak Akabayov

Targeting an RNA hairpin within the ribosomal PTC of M.tuberculosis: AI-Enhanced Molecules for Next-Gen Antibiotics

Ben-Gurion University of the Negev, Israel

17:30-17:45

Valeria Cavalloro

(R)-aloesaponol-III-8-methyl-ether as a new hit against neurodegeneration

University of Pavia, Italy

Flash Poster Presentation Session

chaired by Roman Dembinski

17:45-18:15

Daniela Rossi

Recent advances in anticancer therapy: identification of new allosteric modulators of FGF/FGFR system

University of Pavia, Italy

Antonio Andújar-Arias

Discovery and Optimization of a Novel Class of Positive Allosteric Modulators for the Cannabinoid 2 Receptor

University of Santiago de Compostela, Spain

Ainoa Sanchez Arfelis

Is It Possible to Degrade C-Myc With Low Affinity Compound - Based Protacs?

University of Barcelona, Spain

Roberta Listro

Novel Therapeutic Approaches in Fighting Antimicrobial Resistance: Targeting LsrK in Bacterial Quorum Sensing

University of Pavia, Italy

Ramona Santini

Discotic Amphiphile Supramolecular Polymers for Drug Release and Cellular Activation With Light

The Institute for Bioengineering of Catalonia, Spain

Melania Elettra Vaccari

Sigma receptor modulators for fighting cancer or neuropathic pain: activity switches by small structural changes

University of Pavia, Italy

Kinga Czarnota-Łydka

Triazine-Based Small Molecules as Novel 5-HT6/FAAH Modulators

Jagiellonian University, Poland

Pooja Sharma

Repurposing drugs as 30s translation protein inhibitors to overcome MDR resistant bacterial strains: Computational and In vitro approach

University of Rajasthan, India

Maria Emília Sousa

Synthesis of Marine-Inspired Cyclopeptide Derivatives to Overcome Multidrug Resistance

University of Porto, Portugal

Priscila P. Dario

Knoevengael Adducts From Hydroxychloroquine and 7-chloro-4-aminoquinoline: In Vitro Antiprotozoal Activity Against L. Amazonensis Promastigote Form

Federal University of Paraná, Brazil

S3. Medicinal Chemistry Tales (Part 1)

chaired by Margherita Brindisi

09:00-09:30

Arun Ghosh
Invited Speaker

Beyond Darunavir – Enhancing Protein Backbone Binding to Combat Multidrug-Resistant HIV-1 Variants

Purdue University, USA

09:30-09:45

Stefano Tomassi

Navigating the structure of Cell-Penetrating Nucleopeptides with DNA and RNA Binding Properties

University of Naples Federico II, Italy

09:45-10:00

Ana Mallo-Abreu

Novel Protein Aggregation Inhibitors with Nanomolar Antiplasmodial Potency, High Selectivity Index and Favorable DMPK Properties

University of Barcelona, Spain

10:00-10:15

Javier Sánchez

Improving Neuropathic Pain Relief: Exploring the Potential of Dual Mechanism Compounds through Soluble Epoxide Hydrolase Inhibition

University of Barcelona, Spain

10:15-10:30

Mariana Spetea

Identification and pharmacological characterization of new oxymorphone derivatives as bifunctional mu/delta opioid receptor agonists with antinociceptive efficacy and low-liability profile in mice

CMBI at University of Innsbruck, Austria

10:30-11:00

Coffee Break

S3. Medicinal Chemistry Tales (Part 2)

chaired by Diego Muñoz-Torrero and Simona Collina

11:00-11:30

Xiaoguang Lei
Invited Speaker

Winner of the 2022 Tu You You Award
Translational Chemical Biology

Peking University, China

11:30-11:45

Sveva Pelliccia

Sustainable Rejuvenation of Triazolo Quinoxalin-4(5H)-One Scaffold Synthesis: Chemistry and Preliminary Antimicrobial Evaluation

University of Naples Federico II, Italy

11:45-12:00

Anna Sampietro

New dual sEH-AChE inhibitors with amyloid antiaggregating activity for the treatment of Alzheimer's disease

University of Barcelona, Spain

12:00-12:15

Maria João Matos

Propargylamine-Containing Compounds for Neurodegenerative Diseases: Biological Activity, Physicochemical Properties and Docking Studies

University of Santiago de Compostela, Spain

12:15-12:30

Claudio Viegas Jr.

Design, Synthesis, and Evaluation of Novel Cinnamic Acid-Based N-Acylhydrazone Hybrids as Neuroprotective Agents Against Parkinson's Disease

Federal University of Alfenas, Brazil

12:30-12:45

Rino Ragno

db.3d-qsar.com. The first and unique database of usable 3D QSAR models

Sapienza University of Rome, Italy

12:45-13:00

Group Photograph

13:00-14:30

Lunch Break & Poster Session

S4. Photopharmacological Approaches

chaired by Mariana Spetea

14:30-15:00

Pau Gorostiza
Invited Speaker

Controlling neuronal activity with light: from individual cells to brain waves

ICREA at Institute for Bioengineering of Catalonia, Spain

15:00-15:15

Laia Josa-Culleré

Photoswitching HDAC inhibitors for the spatiotemporal targeting of cancer cells with light

Institute for Advanced Chemistry of Catalonia, Spain

15:15-15:30

F. Javier Pérez-Areales

Red-light modulated photoswitches for peptide stapling

University of Barcelona, Spain

15:30-15:45

Giacomo Rossino

Photoswitchable HuR ligands as an innovative strategy for anticancer agents.

University of Pavia, Italy

15:45-16:15

Coffee Break

S3. Medicinal Chemistry Tales (Part 3)

chaired by Maria Emilia Sousa

16:15-16:45

Maria Duca
Invited Speaker

Design of multifunctional conjugates for the targeting of non-coding RNAs: anticancer and antimicrobial applications

Institute of Chemistry of Nice, Université Côte d'Azur, France

16:45-17:00

Noemi Villella

Discovery of novel and potent human Dihydroorotate Dehydrogenase inhibitor that induces differentiation and apoptosis in Acute Myeloid Leukemia

University of Turin, Italy

17:00-17:15

Adel Nefzi

Combinatorial Chemistry: Application of Natural Product-Inspired Diversity-Oriented Synthesis to Accelerate Drug Discovery

Florida International University, USA

17:15-17.30

Beatriz Büschbell

Unlocking Novel Chemical Matter from Ultra Large Chemical Spaces for ROCK1 and PKA Inhibitors

BioSolveIT, Germany

17:30-17:45

Igor Zhukov

Mechanism of Regulation of Aβ Aggregation by S100B protein in Alzheimer Disease. Analysis interactions S100B with Aβ by 19F NMR Spectroscopy

Institute of Biochemistry and Biophysics, Poland

17:45-18:00

Aitor Valdivia

VF-57: targeting the release of the fusion peptide in influenza A virus hemagglutinin

University of Barcelona, Spain

20:00-22:00

Conference Dinner

S2. RNA-Targeting Small Molecule Drugs and Degraders (Part 2)

chaired by Carmen Escolano

09:00-09:30

Anna Hirsch
Invited Speaker

Dynamic combinatorial chemistry as a powerful hit-identification strategy for challenging targets

Helmholtz Institute for Pharmaceutical Research Saarlan, Germany

09:30-09:45

Pasquale Linciano

Advancing RNA Targeting Strategies: Developing of HuR Ligands and Assessing of STD NMR to Evaluate their capability to disrupt HuR-mRNA Interactions

University of Pavia, Italy

09:45-10:00

Jussara Amato

Ligand-Based Drug Repurposing Strategy and Multiple Biophysical Techniques Identified Viral Rna G-Quadruplex Binders

University of Naples Federico II, Italy

S4. Photopharmacological Approaches (Part 2)

chaired by Claudio Viegas Jr.

10:00-10:30

Wiktor Szymanski
Invited Speaker

Photopharmacology: Towards Light-Controlled Pharmacological Therapy

GRIP, University of Groningen, The Netherlands

10:30-10:45

Luisa Camerin

Photoswitchable carbamazepine analogs for non-invasive neuroinhibition in vivo

Institute for Bioengineering of Catalonia, Spain

10:45-11:00

Xavier Just-Baringo

Visible Light Operated Antimicrobial Peptides: Towards Selective and Resistance-Free Antibiotics

University of Barcelona, Spain

11:00-11:30

Coffee Break

S5. Modulation of Epigenetic Targets

chaired by Marçal Pastor-Anglada
sponsored by IBUB - Institute of Biomedicine of the University of Barcelona

11:30-12:00

Paul Brennan
Invited Speaker

Rare Disease Target Discovery with Epigenetic Chemical Probes

Centre for Medicines Discovery, University of Oxford, UK

12:00-12:15

Simona Barone

Discovery And Characterization Of A New Potent And Selective Histone Deacetylase 6 Inhibitor Against Triple Negative Breast Cancer

University of Naples Federico II, Italy

12:15-12:30

Giulio Rastelli

Targeting Aggressive Prostate Cancer Through HDAC6/HSP90 Dual Inhibitors Based on a 2-Amino-Pyrrolopyrimidine Scaffold

University of Modena and Reggio Emilia, Italy

12:30-13:00

Carles Galdeano
Invited Speaker

First-in-class TET2 activator as a new therapeutic strategy to fight cancer

University of Barcelona, Spain

13:00-14:45

Lunch Break & Poster Session

S6. Covalent Drug Discovery

chaired by Daniea Rossi

14:45-15:15

Luc Brunsveld
Invited Speaker

Fragment-based drug discovery and beyond for molecular glue identification

Eindhoven University of Technology, The Netherlands

15:15-15:30

Massimo Serra

Chemical mannosylation of antigenic elastin-like recombinamers for the development of new glyco-nanovaccine against tuberculosis

University of Pavia, Italy

15:30-15:45

Franz-Josef Meyer-Almes

Identification of unprecedented binding sites at the surface of HDAC8 using electrophilic fragments

Darmstadt University of Applied Sciences, Germany

15:45-16:15

Matthias P. Wymann
Invited Speaker

Targeting PI3Kα – Bridging Gaps with Covalent Proximity Scanning and Rapid Target Engagement

University of Basel, Switzerland

16:15

Award Ceremony and Closing Remarks