11th Molecules Webinar
Synthesis and Identification of Small Compounds Active in Neurodegeneration
Neurodegenerative diseases of the nervous system impose substantial medical and public health burdens on populations throughout the world. Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis are three of the major neurodegenerative diseases with increasing incidence worldwide, associated with the ageing of the population. Several pathological hallmarks have been widely recognized as causes of the loss of specific neurons , including the misfolding and deposition of proteins, oxidative stress and neuroinflammation. Despite increasing awareness and significant research advancements, leading to treatment options that provide a significantly increased quality of life and life expectancy, a delay in the progression of disease and a reduction in symptoms, the development of efficacious therapies has not yet been achieved in this field.
Better elucidation of the molecular mechanisms involved in neurodegenerative diseases can provide an important theoretical basis for the discovery of new and effective strategies for symptomatic treatment. Currently, the development of drugs for the treatment of neurological diseases is limited by the complex challenges posed by the blood–brain barrier, which make it difficult to transport drugs to the brain tissue. Nanosized drug delivery systems are specifically engineered to shuttle drugs across the blood–brain barrier. Moreover, the development of multi-target therapeutics has become an important approach that is widely used in the research in this area, envisaging simultaneous interaction with several pathological targets.
This webinar aims to explore new mechanisms that can serve as targets of therapeutic interventions, as well as some pharmaceutical and pharmacological aspects of neurodegenerative management.
Date: 17 June 2021
Time: 5:00pm CEST | 11:00am EDT | 11:00pm CST Asia
Webinar ID: 891 6385 2550
Webinar Secretariat: molecules.webinar@mdpi.com