
Acute gastroenteritis (AGE) is one of the most common illnesses in humans worldwide, being responsible for half a million deaths among children aged < 5 years, mostly in developing countries. Although in industrialized nations deaths from AGE are rarely seen, gastrointestinal diseases remain an important cause of morbidity in younger children resulting in substantial medical and healthcare expenses, lost productivity, and other costs to society and families. Enteric viruses have been recognized as the most significant etiologic agents of AGE in children and four viruses are being considered as clinically relevant: group A rotavirus (RVA), norovirus (NoV), adeno virus 40/41 (AdV) and astrovirus (AstV). These viruses are characterized by a high genetic and antigenic variability, due to evolutionary mechanisms such as rearrangement, re-assortment, inter-species transmission and positive accumulation of point mutations. The continuous emergence and re-emergence of several variants poses challenge for their classification, but also for development of diagnostics assays and suitable vaccines. The aim of this webinar is to focus on the temporal pattern of evolution of the main enteric viruses. In particular, large-scale surveillance studies on RVA, NoV and AstV will be showed in order to update information about their genetic evolution over the time. Moreover, the experience acquired on RVA vaccine will be presented to underline the importance of molecular epidemiology investigation as a valuable baseline information for new vaccines development.
Date: 28 September 2021
Time: 3:30pm CEST | 9:30am EDT | 9:30pm CST Asia
Webinar ID: 881 3272 0184
Webinar Secretariat: pathogens.webinar@mdpi.com
Guest Editors: Prof. Dr. Simona De Grazia, Dr. Floriana Bonura
Deadline for manuscript submissions: 1 October 2021