Thursday 8 September 2022

10:00 – 10:10

Welcome from the Chairs & Introduction

Biosensors and Biodevices

Chair: Victor C. Diculescu

10:10-10:40

10:40-11:10

Madalina Barsan - Proteasome biosensors and immunosensors for new diagnostic strategies and drug therapies in various diseases

Ricardo Leote - Bienzymatic Biosensor for Pyruvate Kinase Inhibitors Screening for Cancer Treatment

11:10-11:40

11:40-11:50

Coffee Break

Biomimicking and Biobarriers

Chair: Maria João Moreno

11:50-12:45

Vanessa Domingues - Structure and stability of alpha-gliadin under INFOGEST-standard conditions

Alejandro Samhan Arias - Structural characterization of caveolin-2 for generation of membrane nanodomains

Dorinda Marques da Silva - Synthetic membranes as an alternative model to animal skin to investigate dermal permeation of chlorpyrifos

Cristiana Pires - Bioavailability and biotransformation of paralytic shellfish toxins assessed by permeability assays using Caco‐2 monolayers

12:45-13:15

Lino Ferreira - Models and formulations to overcome the blood-brain barrier

13:15-14:15

Lunch

Immunomodulation

Chair: Paula Videira

14:15-14:50

Emma Browne - The cytotoxicity of phorbol 12- myristate 13-acetate and lipopolysaccharide on THP-1 cells and optimized differentiation protocol

Mariana Barbosa - Targeting immune-mediated responses to tackle GNE myopathy

Materials and Drug Delivery

Chair: Mário Diniz

14:50-15:20

Quim Peña - Metal-based cancer (nano)medicine

15:20-15:30

Coffee Break

15:30-16:20

Carlos Coelho - BSA‐PEG hydrogel: A novel protein‐ligand binding 3D matrix

Anca Aldea - Flexible sensors based on metallized electrospun polymeric fibers for sweat analysis

Alexandra Pusta - Magnetic nano-carriers for the targeted delivery of antitumor drug sorafenib

Cristiana Violante - Promotion of dermal permeation of bioactive compounds using a microneedle device

16:20-16:50

Victor C. Diculescu - Electrospining for electrochemical applications

16:50-17:00

Closing Remarks

Friday 9 September 2022

Targets and Advances in Pharmacology

Chair: Ricardo Lagoa

10:00-10:30

Carlos Gutiérrez Merino - High-affinity molecular targets of amyloid β (1-42) peptide oligomers in neurons

10:30-11:15

Arnab Banerjee - Small extracellular vesicles (sEVs) imaging for clinical applications

Sofia Viana - A voluntary, metabolic inert and animal welfare friendly tool for oral drug dosing – pill tech

Akhileshwar Srivastava - In silico screening of the therapeutic paradigm of curcuminoids relative to conventional drugs for inactivation of SARS-CoV2 receptors

11:15-11:25

Coffee Break

11:25-12:00

Poster Sessions - 2 Parallel sessions for Flash Presentations

Chairs: Dorinda Silva and Joaquim Rui Rodrigues

Session I (room 1):

Andreia Vilaça - Proteomic profiling of extracellular vesicles identifies source-specific molecular signature

Caroline Sanz - Electrochemical characterization of shikonin and in-situ evaluation of interaction with DNA

Daniela Oprea - Polymer nanofibers support for biosensing application in cell cultures

Inês Ferreira - Deep eutectic systems: What methodology should we use to assess toxicity?

Iris Correia - An insight into the nutritional profile and antioxidant activity of the sea fennel halophyte plant (Crithmum maritimum)

Session II (room 2):

Daciana Botta - Electrochemical Devices with Metallized Electrospun Fiber Meshes Electrodes

Mihaela-Cristina Bunea - Degradation of azathioprine and its effects on DNA

Magdolna Casian - Selection, characterization and use of Protein Golgi 73 specific aptamer as a tool for early-stage diagnosis of hepatocellular cancer

Gil Fraqueza - Pharmacological, Antimicrobial and Toxicological Actions of Vanadium Compounds

Magda Rodrigues - Freeze-dried small extracellular vesicles (sEVs): the next step for sEV clinical applications

Zélia Silva - Oxidative stress and inflammatory response of fibroblasts exposed to chlorpyrifos

Advances in Toxicology

Chair: Judite Vieira

12:00-12:45

Vera Costa - Cardio-oncology: something old, something new, something bowered and something blue

João Lopes - Use of lipid vesicles for revealing the potential contribution of cytochrome c in the metabolism of environmental toxicants

Inês Rodrigues - Effects of atmospheric particulate matter (PM) in exposed Mytilus galloprovincialis

12:45-13:15

Félix Carvalho - Toxicology of the XXI century

13:15-14:15

Lunch

14:15-15:15

Special Session: Environmental Health and Human Toxicology - from the Lab to the Field

Chairs: Dorinda Silva, Silvia Scaglione and Ethel Eljarrat

Metallodrugs

Chair: Manuel Aureliano

15:15-15:45

Ignacio León - Finding new molecular targets of Copper(II) complexes on triple negative breast cancer cells using mass spectrometry-based quantitative proteomics

15:45-15:55

Coffee Break

15:55-16:20

Ricardo Lagoa - The growth curve method to rapidly derive the antibacterial potential of polyoxovanadates

Diana Pereira - Silver-based nanoparticles as powerful pathogen-killing agents

16:20-16:50

Debbie C. Crans - Potential applications of vanadium-based anticancer drugs for intratumoral injections

16:50-17:00

Closing Remarks