Because of the harmful effect of the environment, the use of SF6 is restricted and its alternatives are investigated. Among those alternatives, vacuum circuit breaker gain a crucial role at mostly in medium voltages.In this study, the capacitive current test, electrical endurance test and mechanical operation test are investigated among why they are crucial and what those means with the insulation way of thinking.

UV spectrophotometric method was developed for the determination of dapagliflozin in pure form and in tablets. The method was developed using methanol and water as diluents. The results were achieved by using two methods: absorbance maxima and area under the curve method. All the parameters were chosen according to ICH [Q2(R1)] guideline and validated statistically using RSD and %RSD. The results of validation parameters were within the range. The developed method is accurate and precise.

Flavonoids are known to showcase anti-inflammatory abilities. Hence, it is not a wild guess that they might inhibit NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome signaling, implying these chemicals could inspire new drug candidates for this specific pathway. As such, this work aims to identify flavonoids as potential NLRP3 inhibitors, virtually screening 100 known compounds through molecular docking, with subsequent Molecular Dynamics (MD) and MM/PBSA analysis of the two best performing ligands. It was found that Dorsmanin C (DC) and Poinsettifolin A (PA) performed best out of all compounds screened, both satisfying screening criteria determined in docking method validation and predictably binding to key residue Arg⁵⁷⁸, essential for activity. In MD simulations, PA was observed to be bound steadier to NLRP3 than DC and NP3-146, a known inhibitor, as demonstrated by RMSD, RMSF, Rg and SASA values, although underperforming in H-bonds and ligand stability when compared to NP3-146. MM/PBSA calculations describe lower binding energy for NP3-146 when compared to PA and DC, yet PA still proves superior to DC in terms of target affinity. Therefore, Poinsettifollin A presents as the most promising candidate, highlighting it as a potential lead for development of novel anti-inflammatory drugs.

É fundamental compreender a vida de prateleira e a qualidade dos óleos vegetais, uma vez que esses fatores são significativamente influenciados pelo valor de peróxido (PV), um indicador crítico da oxidação lipídica [1]. A oxidação lipídica não só altera as propriedades sensoriais e nutricionais dos óleos, mas também leva à formação de hidroperóxidos, afetando o odor e a qualidade geral. Tradicionalmente, a VP é medida através de titulação iodométrica, onde o iodo é liberado em reação aos peróxidos [1]. No entanto, a demanda por métodos mais rápidos, eficientes e ambientalmente amigáveis tem levado à exploração de técnicas espectrofotométricas [1]. Essas técnicas, incluindo o método da Federação Internacional de Laticínios (IDF), envolvem a oxidação de íons Fe(II) a Fe(III) formando complexos coloridos, oferecendo uma alternativa potencial aos métodos titrimétricos [1].

Este estudo avalia e compara a eficácia destes métodos espectrofotométricos contra a abordagem iodométrica tradicional na determinação do PV em óleos vegetais. Focaliza, particularmente, a viabilidade do uso da análise espectrofotométrica para quantificação de PV, visando fornecer uma alternativa mais rápida e limpa. O estudo também explora vários solventes como isopropanol e misturas de metanol, etanol e n-hexano como substitutos potenciais na medição fotovoltaica.

Resultados preliminares sugerem que esses métodos alternativos, especialmente quando emparelhados com as misturas de solventes certas, podem efetivamente determinar o PV, oferecendo um substituto viável para o procedimento de titulação padrão. Esse avanço pode atender à crescente necessidade de avaliações fotovoltaicas rápidas e ecológicas na indústria de alimentos. Os resultados são significativos, prometendo abordagens mais simplificadas e sustentáveis para garantir a qualidade e a segurança dos óleos vegetais.

Gestational diabetes mellitus (GDM) is glucose intolerance that occurs during pregnancy and can lead to various pregnancy complications. A common genetic factor proposed to be involved in GDM are polymorphisms in the vitamin D receptor (VDR) gene. Vitamin D binds to the VDR gene and leads to the transcription of other genes. Mutations in the VDR gene will impact the effect of vitamin D on the receptor. Vitamin D is involved in the implantation, differentiation, and growth of foetal cells and VDR polymorphisms have been associated with the occurrence of GDM, but findings are contradictory. We assessed the relationship between GDM and VDR polymorphisms. This systematic review and meta-analysis based on the association between VDR polymorphisms and GDM, retrieved from PubMed central, Medline, Google Scholar, EBSCOhost, LILACS, Cochrane Library, ScienceDirect, and Web of Science Core Collection databases. The eligibility of studies was assessed by the two independent reviewers with third reviewer serving as arbitrator following specific criteria. data was analysed with the Review Manager (RevMan) 5.3 software. This systematic review and meta-analysis revealed no statistical difference between GDM and control group for rs7975232, rs10735810, and rs731236 [OR = 1.08 (0.91, 1.28); p = 0.36], [OR= 0.81 (0.57,1.14); p = 0.22], and [OR=1.80 (1.31, 2.46) p= 0.0002] respectively. VDR gene polymorphisms rs7975232, rs10735810 and rs731236 are not associated with gestational diabetes mellitus. The rs731236 has protective effects against GDM, whereas rs10735810 increases susceptibility to GDM. Further studies with lager sample size especially in low middle income countries are needed to confirm these findings.