Tetramethylammonium Fluorochromate has been found to oxidize alcohols to corresponding aldehydes and ketones. Without polymerization of double bonds, over oxidation and other side reactions. This reagent has been found that effective for oxidation of thiols to disulphides.

Cyclic acetals and ketals play the important role in the synthetic chemistry of carbohydrates and widely utilized in specific protections for simultaneously two or more hydroxyl groups. In particular, alkylidene derivatives of monosaccharides are formed from interaction of these ones or their derivatives with aldehydes or ketones in the presence of acid as catalyst [1-5]. In all of alkylidene derivatives, the ethylidene ones of monosaccharides have received more attention than other particularly for the synthesis partially substituted sugars.

The series of twenty lipophilic 2-aryl-5,7-di-tert-butylbenzoxazoles substituted in the phenyl ring was prepared by the reaction of 2-amino-4,6-di-tert-butylphenol with the appropriated aldehydes. The general synthetic approach of all newly synthesized compounds is presented. All the substituted 5,7-di-tert-butylbenzoxazole derivatives were analyzed using the reversed phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using end-capped non-polar C₁₈ stationary RP column. In the present study the correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and log P data calculated in various ways is shown. The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well.

Some substituted acetylpyrazine derivatives were prepared as the starting materials for the subsequent synthesis of N,N-dimethylthiosemicarbazones. General synthetic approach of all newly synthesized compounds is presented. All the N,N-dimethylthiosemicarbazone derivatives of acetylpyrazines were analyzed using the reversed phase high performance liquid chromatography (RP-HPLC) method for the lipophilicity measurement. The procedure was performed under isocratic conditions with methanol as an organic modifier in the mobile phase using end-capped non-polar C₁₈ stationary RP column. In the present study the correlation between RP-HPLC retention parameter log K (the logarithm of capacity factor K) and log P values calculated in various ways is discussed as well as the relationships between the lipophilicity and the chemical structure of the studied compounds.

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The asymmetric aza-Diels-Alder reaction of chiral imines with Danishefsky’s diene in chiral ionic liquids provides the corresponding cycloadduct with moderate to high diastereoselectivity. The reaction has proved to perform better at room temperature in ionic liquids without either Lewis acid catalyst or organic solvent. Chiral ionic liquids are recycled while their efficiency is preserved.

DDQ was employed as a dehydrogenation reagent to synthesized polyaromatic compounds. These compounds may have biological properties, especially antitumoral activity, due to their planar configuration.

Substitued 3-amino-2-cyanothiophenes condensed with cyclic ketones afforded in 2 or 3 steps analogues of velnacrine. Condensation under Friedländer conditions gave Tacine analogues in one step.

The reaction of 2-amino-4-aryl-3,4-dihydro[1,3,5]triazino[1,2-a]-benzimidazoles with diethyl ethoxymethylenemalonate was found to afford 6-aryl-3-carbethoxy-4-oxo-4,6-dihydro-1(12)(13)H-pyrimido[2’,1’:4,5][1,3,5]triazino[1,2-a]benzimidazoles. The structure of the compounds obtained was established using NMR spectroscopy, including 2D NOESY experiments.

The reaction of 2-guanidino-4-quinazolinone with arylaldehydes was found to afford 2-amino-4-aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones. The structures of the compounds obtained were established using NMR spectroscopy, including 2D NOESY experiments.