Xanthane hydride (5-Amino-3H-1,2,4-dithiazole-3-thione) reacts with primary amines (1 eq.) and HCHO (2 eq.) under harsh conditions (reflux in DMSO) to give a hitherto unknown heterocyclic system, 6,7-dihydro-3H,5H-[1,2,4]dithiazolo[4,3-a][1,3,5]triazine. The products were confirmed by NMR studies.

Coumarin is found in a variety of plants such as Tonka bean, Lavender, sweet clover grass, Licorice and also occurs in food exists plants such as strawberries, apricots, cherries, cinnamon. Coumarin derivatives have blood-thinning, anti-fungicidal, anti-tumor and anticoagulant activities. Photophysics and photochemistry of coumarin derivatives are also important.[1] With reaction between 6-Aminocoumarin and pyridine-2-carboxaldehyde we synthesized N-[(2-pyridyl)methyliden]-6-coumarin (L) [2,3]. The ligand, L added to hexachloroplatinic acid to synthesize a Pt(IV) complex of formula [Pt(L)₂]Cl₆ and [Pd(L)₂]Cl₂. On the other hand, the reaction in the attendance of pyrocatechol has isolated [Pt(L)(1,2-dihydroxybenzene)₂]Cl₆. The compound is characterized by FTIR, UV–Vis and ¹H NMR spectroscopic data. 

References

[1] J.N. Deams, G.A. Crosby, J. Phys. Chem. 75 (1971) 991.

[2] B. Valuer, Molecular Fluorescence: Principles and Applications, Wiley–VCH,

Weinheim, 2001.

[3] Suman Roy , Tapan Kumar Mondal , Partha Mitra , Elena Lopez Torres , Chittaranjan Sinha , Polyhedron 30 (2011) 913.

Benzimidazole derivatives are compounds of great interest by their applications as pharmaceuticals, exhibiting a variety of biological applications. However, few samples of benzimidazoles linked to monosaccharides are described. Herein, we report the synthesis of benzimidazoles from D-glucose derivatives.

A series of 6-amino-4-substituted-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles 5(a-j) as a potent anticancer agent were synthesized via one-pot, four-component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile, and hydrazine hydrate in solvent-free conditions using ionic liquid [Et₃NH][HSO₄] as an efficient, eco-friendly and reusable catalyst. The Multi component coupling reactions (MCRs) indicate a highly appreciated synthetic tool for the establishment of novel and complex molecular scaffold with a minimum number of synthetic steps with the advantage like shorter reaction times, lower costs, high degrees of atom economy etc. From the literature survey it is found that dihydropyrano[2,3-c]pyrazole derivatives posses very important biological activities, including anticancer, antiinflammatory, antimicrobial, inhibitors of human Chk1 kinase, molluscicidal, and insecticidal activities. The solvent used in conventional organic synthesis are suffered by many disadvantage like environmental hazards, toxicity, volatile nature, expensive etc. A new term ‘designer solvents’ referring to Ionic liquids because of their adjustable physical and chemical properties with the change in selected cationic and anionic combination. Ionic liquids have become a promising alternative media for various chemical processes due to their properties including good solvating capability, negligible vapour pressure, non-inflammability, ease of recyclability, controlled miscibility and high thermal stability. Herein we are reporting the use of acidic Bronsted ionic liquid(ABILs) [Et₃NH][HSO₄] triethyl ammonium sulphate for the synthesis of biologically important scaffold 6-amino-4-(substituted phenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile . Compared to other methods, this new method has advantages, such as excellent yields, a short reaction time, mild reaction conditions and catalyst reusability. The synthesized derivatives 5(a-j) were characterized by FTIR, ¹HNMR, ¹³CNMR and mass spectral data.

The main objetive of this work is the synthesis of epoxy nanocomposites with gold nanoparticles. The curing process was optimized by microwave taking into account variables such as time and temperature.