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Isoprene-mediated lithiation of chiral N-alkylimidazoles
Published:
30 November 2007
by MDPI
in The 11th International Electronic Conference on Synthetic Organic Chemistry
session General Organic Synthesis
Abstract: The isoprene-mediated lithiation of different chiral N-alkylimidazoles (2a and 2b) and the following reaction with pivalaldehyde leads to the corresponding imidazolylpropanol derivatives 4 and 5 with excellent overall yield, but low de (up to 26%).
