Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation

Wai-Keung Chui; Anna Dolzhenko; Boris Syropyatov; Olga Sherbakova; Dmitry Kalinin; Svetlana Ustinova; Anna Krasnova; Anton Dolzhenko

doi:10.3390/ecsoc-11-01336

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Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation

Wai-Keung Chui

¹,

Anna A. Dolzhenko

¹,

Boris Ya. Syropyatov

^{*

2},

Olga V. Sherbakova

²,

Dmitry V. Kalinin

²,

Svetlana A. Ustinova

²,

Anna A. Krasnova

²,

Anton V. Dolzhenko

^{*

1}

¹ Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore
² Department of Physiology, Perm State Pharmaceutical Academy, Perm, Russian Federation

Published: 30 November 2007 by MDPI in The 11th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-11-01336

Abstract: (Het)arylamidoguanidines were synthesized from corresponding hydrazides and S-methyl isothiourea. They were screened in vitro for anticoagulant activity using whole canine blood. The most active compounds, namely 4-methylbenzamidoguanidine and nicotinamidoguanidine were also tested on platelet free plasma. No effect was observed for these compounds on the clotting time of platelet free plasma. Therefore, platelets were suspected as a possible target for the anticoagulant activity of the (het)arylamidoguanidines.

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Wai-Keung Chui

Anna Dolzhenko

Boris Syropyatov

Olga Sherbakova

Dmitry Kalinin

Svetlana Ustinova

Anna Krasnova

Anton Dolzhenko