Abstract: Symmetrical and asymmetrical triphenylene-based discotic liquid crystals with mixed ether-ester peripheral chains, the ester ones with a chiral carbon [ abbreviated as sym-TP(OCnH2n+1)3(OOCC*HClCH2CHMe2)3 and asym-TP(OCnH2n+1)3(OOCC*HClCH2CHMe2)3, n = 4 ~ 8，11 ] were synthesized. The phase transition temperature and the liquid crystal states were determined with polarized optical microscopy (POM) and differential scanning calorimetry (DSC). It was found that the symmetrical isomers have lower clearing points. Some of the discogens show as many as three kinds of columnar mesophases.