New Bis-Urea Cross-Linking Monomers as Effective Oxyanion Receptors

Christophe Gomy; Andreea Schmitzer

doi:10.3390/ecsoc-9-01514

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New Bis-Urea Cross-Linking Monomers as Effective Oxyanion Receptors

Christophe Gomy

Andreea R. Schmitzer

¹ Department of Chemistry, Université de Montréal, C.P. 6128 Succursale, Centre-ville, Montréal, Québec, H3C 3J7, Canada

Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-9-01514

Abstract: A library of new polymerizable functional cross-linking monomers designed for complexation with the oxyanionic moiety of the chemotherapeutic drug methotrexate (MTX). The 1H NMR binding study of a variety of synthetic receptors and the compilation of the obtained results lead to the identification of monomers combining interactive functionality and a cross-linking format, specific binding receptors for dicarboxylate-containing drugs.

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Christophe Gomy

Andreea Schmitzer