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(S)-5-(Tosylmethyl)-2-pyrrolidinone: A New Chiral b -Amidosulfone for a Short Asymmetric Synthesis of Indolizidines
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1  Departamento de Quimica Organica, Universidad de Alicante. E-03080 Alicante, Spain

Abstract: The synthesis of (S)-5-(tosylmethyl)-2-pyrrolidinone from (S)-pyroglutaminol [(S)-2-(hydroxymethyl)-2-pyrrolidinone] in three steps and its applications into the synthesis of indolizidines is described in this communication.
Keywords: Asymmetric synthesis, Sulfones, Indolizidines, Dianions, Alkylation

 
 
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