Trimethylsilyl Triflate Promoted 1,4-Addition of Silyl Phosphites to Cyclic Enones

Ichiro Mori; Yoko Kimura; Toshihito Nakano; Shin-ichiro Matsunaga; Genji Iwasaki; Atsuko Ogawa; Kenji Hayakawa

doi:10.3390/ecsoc-1-02023

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Trimethylsilyl Triflate Promoted 1,4-Addition of Silyl Phosphites to Cyclic Enones

Ichiro Mori

^{*

1},

Yoko Kimura

²,

Toshihito Nakano

²,

Shin-ichiro Matsunaga

^{*

3},

Genji Iwasaki

²,

Atsuko Ogawa

²,

Kenji Hayakawa

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
² Chemistry Department, International Research Laboratories,Ciba-Geigy Japan Ltd, P.O.Box 1, Takarazuka 665, Japan
³ Medicinal Chemistry Group, Research, Novartis Pharma K.K., 10-66, Miyuki-cho, Takarazuka, 665 Japan

Published: 01 September 1997 by MDPI in The 1st International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-1-02023

Abstract: A catalytic amount of trimethylsilyl triflate (TMSOTf) remarkably facilitated the selective conjugate addition of a variety of silyl phosphites, prepared in situ from dialkyl phosphites and N,Obis( trimethysilyl)acetamide, to cyclic enones giving 1,4-adducts in high yields.

Keywords: n/a

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