Synthesis of Triethylammonium 4-Aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-olates: 1-Cyanoacetyl-3,5-dimethylpyrazole as an Effective Alternative to Cyanoacetic Ester in Guareschi Reaction

Victor Dotsenko; Elena Chigorina

doi:10.3390/ecsoc-15-00702

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Synthesis of Triethylammonium 4-Aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-olates: 1-Cyanoacetyl-3,5-dimethylpyrazole as an Effective Alternative to Cyanoacetic Ester in Guareschi Reaction

Victor Victorovich Dotsenko

^{*

1},

Elena Anatolyevna Chigorina

^{2, 3}

¹ ChemEx Laboratory, Vladimir Dal’ East Ukrainian National University, kv Molodezhny 20-A 7/309, 91034 Lugansk
² Chemical Diversity Research Institute, 2a-1 Rabochaya St., Khimki, Moscow region, 141400 Russia
³ Research Institute of Plastics, Perovsky proezd 35, 111024, Moscow, Russia

Published: 25 October 2011 by MDPI in The 15th International Electronic Conference on Synthetic Organic Chemistry session General Organic Synthesis

https://doi.org/10.3390/ecsoc-15-00702

Abstract: Triethylammonium 4-aryl-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-olates were obtained by reaction of (E)-3-aryl-2-cyanoacrylamides with 1-cyanoacetyl-3,5-dimethylpyrazole in the presence of 1.5 eq. of Et₃N (20 °C, acetone) in 55-98% yields.

Keywords: Guareschi reaction, 1-cyanoacetyl-3,5-dimethylpyrazole

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Victor Dotsenko

Elena Chigorina