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An original method for the synthesis and the study of its biological activity of natural lembehyne B aromatic analogs.
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Academic Editor: Julio A. Seijas
Published:
12 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
In the development of earlier initiated studies on the synthesis of natural and synthetic neuritogenic alkynols, lembehynes A-C, which, simultaneously, exhibit high antitumor activity, we have developed a method for the synthesis of an analogue of natural lembehyne B containing a phenyl radical in its structure. It has been shown that the synthesized aromatic analogue of lembehyne B exhibits higher antitumor activity in vitro to a number of tumor cell lines (Jurkat, K562 and U937).
Keywords: Antitumor activity, aromatic analogue of lembehyne B.
