Synthesis of new functionally substituted bicyclo[4.2.1]nona-2,4,7-trienes by Co(I)-catalyzed [6&pi;+2&pi;] cycloaddition of 1-benzoylcycloheptatriene

Gulnara Kadikova; Lilya Dzhemileva; Usein Dzhemilev

doi:10.3390/ecsoc-25-11631

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Synthesis of new functionally substituted bicyclo[4.2.1]nona-2,4,7-trienes by Co(I)-catalyzed [6π+2π] cycloaddition of 1-benzoylcycloheptatriene

Gulnara Kadikova

^*,

Lilya Dzhemileva

Usein Dzhemilev

¹ Institute of Petrochemistry and Catalysis of RAS (IPC RAS)

Academic Editor: Julio A. Seijas

Published: 12 November 2021 by MDPI in The 25th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic, Medicinal and Natural Products Chemistry

https://doi.org/10.3390/ecsoc-25-11631

Abstract:

Functionally substituted bicyclo[4.2.1]nona-2,4,7-trienes were synthesized for the first time on the basis of the reaction of [6π+2π] cycloaddition of hexyn-1 and 4-pentynenitrile to 1-benzoylcycloheptatriene under the action of the three-component catalytic system Co(acac)₂(dppe)/Zn/ZnI₂

Keywords: [6π+2π] cycloaddition; 1-benzoylcycloheptatriene; alkynes; bicyclo[4.2.1]nona-2,4,7-trienes; cobalt(II) acetylacetonate; antitumor activity

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Gulnara Kadikova

Lilya Dzhemileva

Usein Dzhemilev