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Stereoselective synthesis and cytotoxic activity of aromatic polyether macrodiolides containing 1Z,5Z-diene moiety
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Academic Editor: Julio A. Seijas
Published:
15 November 2021
by MDPI
in The 25th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
The synthesis of previously undescribed aromatic polyether macrodiolides, containing a 1Z,5Z-diene moiety was carried out in 56-72% yields and with >98% stereoselectivity. It has been shown that the synthesized macrodiolides exhibits higher cytotoxic activity in vitro to a number of tumor cell lines (Jurkat, K562 and U937).
Keywords: 1,5-Dienoic compounds; Crown Ethers; Cyclomagnesiation; Macrodiolides; Cytotoxicity;
