The climatological characterization of variables, allows us to understand the average behavior of atmospheric conditions, detect extremes and fluctuations, relationships of variables with geographic physical factors and is presented as another alliance for weather forecasting. The aim of this research is characterize the behavior of the meteorological variables at the Antonio Maceo International Airport in Santiago de Cuba, in the period 2017-2021. Antonio Maceo International Airport has the particularity of being located in a complex relief, exposed to marked breeze influences, and a significant number of wind shear pilot reports. The characterization was based on the concepts and graphs of descriptive statistics. The mean monthly distribution of the variables: temperature, relative humidity, atmospheric pressure, and wind speed and direction was obtained and represented. The distributions of the maximum monthly and annual accumulations, the cloud cover and the ranges of the reduction of the horizontal and vertical visibility were analyzed.