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Semisynthesis of 6β-acetoxyvouacapane derivates via the Ugi-azide multicomponent reaction
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Academic Editor: Julio A. Seijas
Published:
14 November 2022
by MDPI
in The 26th International Electronic Conference on Synthetic Organic Chemistry
session Bioorganic, Medicinal and Natural Products Chemistry
Abstract:
A semisynthesis of 6β-acetoxyvouacapane-1,5-disusbtituted tetrazoles derivates from the leaves of Caesalpinia platyloba by using the Ugi-azide multicomponent reaction as a key step reaction is described. To our knowledge, this is the first report where a non-natural product such as 1,5-disusbtituted tetrazole is linked to a natural product or derivate of a natural product, and beyond the biological relevance that the target molecules present, this work contributes to the area of natural products as well as multicomponent reactions
Keywords: 6β-acetoxyvouacapane; 1,5-disusbtituted tetrazoles; Ugi-azide; isocyanides; semisynthesis
