New Bis-Urea Cross-Linking Monomers as Effective Oxyanion Receptors

Christophe Gomy; Andreea Schmitzer

doi:10.3390/ecsoc-9-01514

Previous Article in event

Synthesis and Biological Evaluation of Pyrazinecarboxamides

Next Article in event

Synthesis and Dihydrofolate Reductase Inhibitory Activity of 2-amino-[1,3,5]triazino[1,2-a]benzimidazoles

New Bis-Urea Cross-Linking Monomers as Effective Oxyanion Receptors

Christophe Gomy

Andreea R. Schmitzer

¹ Department of Chemistry, Université de Montréal, C.P. 6128 Succursale, Centre-ville, Montréal, Québec, H3C 3J7, Canada

Published: 01 November 2005 by MDPI in The 9th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products

https://doi.org/10.3390/ecsoc-9-01514

Abstract: A library of new polymerizable functional cross-linking monomers designed for complexation with the oxyanionic moiety of the chemotherapeutic drug methotrexate (MTX). The 1H NMR binding study of a variety of synthetic receptors and the compilation of the obtained results lead to the identification of monomers combining interactive functionality and a cross-linking format, specific binding receptors for dicarboxylate-containing drugs.

View paper

45 Reads
0 Recommendations

Christophe Gomy

Andreea Schmitzer