The use of food and its nutrients as a remedy for diseases is historically, and culturally well-rooted in plenty of societies. An example of this it’s the use of Hibiscus sabdariffa to treat conditions like hypertension or high blood glucose. Furthermore, the natural biocompounds present in this plant have been associated by several authors as hypotensive, anti-oxidant, anticarcinogenic, antiobesogenic, etc. One of those compounds it’s Delphinidin-3-Sambubiosid (DS3) its the most representative anthocyanin of Hibiscus sabdariffa, and as such, it has by large been attributed with the beneficial effects previously mentioned. However, little is known about the molecular targets that DS3 actually has. Therefore, we made an in-silico analysis using different bioinformatic tools in order to see the possible molecular targets of this molecule and the potential impact the modification of its targets could have on protein and/or pathways of humans as a whole. We used the Swiss Target Prediction site to identify all the molecular targets of DS3, then, ShinnyGo 0.77, KEGG, and Stringdb were helpful to identify key pathways and hub genes related to them. Also, a literature search was made in PubMed where each of the hub genes were linked to DS3 so we could gather information that complemented the results of the bioinformatic tools. The results showed that DS3 can modify the behavior of genes related to nitrogen and glucose metabolism, inflammation, angiogenesis, and cell proliferation. Additionally, DS3 directly affects the PI3K-AKT pathway, which could be a key finding to promote further research, especially in the implications associated with changes in the pathway as mentioned earlier.
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Effects of Delphinidn-3-sambubiosid in different pathways of human cells according to a bioinformatic assay.
Published:
01 November 2023
by MDPI
in The 3rd International Electronic Conference on Nutrients
session Nutriomics Approaches in Precision Nutrition
Abstract:
Keywords: Hibiscus sabdariffa; Delphinidin-3-sambubiosid; Bioinformatics
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