Effective water resource management is crucial in the face of increasing climate variability and change, which adversely affects water availability, glacier melting, agriculture, biodiversity, and food accessibility. This study advocates for a comprehensive and collaborative framework that integrates sustainable practices, risk management, and adaptive strategies. It underscores the necessity of interdisciplinary cooperation among governmental agencies, communities, and scientific experts to ensure equitable and sustainable water resource management. By addressing various water uses—domestic, agricultural, industrial, and ecological—this approach seeks to balance competing demands and minimize conflicts. A crucial element of this integrated strategy is climate resilience, which involves anticipating risks such as droughts, floods, and shifting precipitation patterns. Key strategies include developing robust infrastructure, implementing water-saving technologies, and preserving natural water systems. Furthermore, proactive policies and practices are essential to enhance the adaptive capacity of communities and ecosystems, securing long-term water availability and ecosystem health. Integrating traditional knowledge with innovative technologies further strengthens the effectiveness of water management practices. This holistic approach not only safeguards water resources but also fosters socio-economic development and environmental sustainability. By promoting resilience and adaptability, integrated water resource management can effectively mitigate the adverse impacts of climate change, ensuring water security for future generations and supporting sustainable development goals.